![]() ![]() Ī variety of dressings are currently available for superficial partial-thickness burns, such as silver-impregnated, alginate, hydrocolloid, hydrogel, silicone-coated nylon, polyurethane film or biosynthetic dressings, without a gold standard being defined. Subsequently, there is a great demand for treatment options capable of achieving early and complete wound coverage while retaining normal skin function. Even if available, outcomes may be suboptimal, including significant donor site morbidity. However, split-thickness skin grafting may not be possible, e.g., in extended burns with limited donor skin availability. In deep dermal and full-thickness burn injuries, early excision and application of split-thickness skin grafts is the established main treatment option to achieve early wound closure and avoid common complications such as sepsis, multi-organ failure and acute kidney injury. Future larger cohort studies are warranted to elucidate the full potential of this promising approach.īurn wound healing and management as a complex and long-lasting process continues to represent a major challenge for patients and health care providers resulting in considerable socio-economic burdens. However, results mainly originate from preclinical and small cohort studies. Conclusions: Acellular fish skin xenografts may represent an effective, low-cost alternative in treatment of superficial- and partial-thickness burns. Existing evidence on the use of acellular fish skin indicates an acceleration of wound healing, reduction in pain and necessary dressing changes as well as treatment-related costs and improved aesthetic and functional outcomes compared to conventional treatment options. ![]() Results: In total, 14 trials investigating the effects of acellular fish skin in burn wounds or split-thickness donor sites were determined eligible and included in the present review. Titles and abstracts were screened for the following key terms (variably combined): “fish skin”, “fish skin grafts”, “acellular fish skin”, “Omega3 Wound matrix”, “xenograft”, “burn injury”, “burns”. Materials and Methods: A systematic review of the literature, up to March 2022, was conducted using the electronic databases PubMed and Web of Science. Due to these beneficial wound healing properties, acellular fish skin might represent an effective treatment approach in burn wound management. Acellular fish skin acts as a skin substitute, reducing inflammatory responses and advancing proinflammatory cytokines that promote wound healing. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development of acellular fish skin. Wounds may also close faster, with patients reporting less pain when treated with fish skin over the traditional silver sulfadiazine, according to various research.Background and Objectives: Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Tilapia skin has been shown to be more resistant than the previously used pig skin, which enables it to withstand stretching. The skin is then removed after around one week, with no need for daily dressing changes, the report noted. It can then be stored for up to two years if refrigerated, before simply being cut to size and placed over a burn instead of a bandage. Once sterilized, Tilapia skin undergoes radiation therapy to kill any lingering viruses. "In relation to children, the skin ends up being kind of playful, like: 'Gaining a skin and looking like a superhero,'" Rocha said. "With the passage of time and the success of the research, patients will arrive at the hospital wanting the treatment with the skin of the Tilapia. "The major concerns were whether the skins would subsequently come off, if the fish odor would remain," Rocha was quoted as saying to The Times. Although many patients can be reluctant to have fish skin wrapped around their burns, a growing number of children are actually arriving at hospital requesting the "bandage," the report said. ![]()
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